Theme: Longitudinal Analysis

Analysis of human brain development is a crucial step for improved understanding of neurodevelopmental disorders.

We focus on brain development as observed in neonates and children. We characterize brain development through analysis of contrast changes in MRI and DTI of children undergoing healthy brain development as well as in children at risk of neurological disorders. We discuss spatio-temporal brain development using voxel-based analysis, atlas-based ROI analysis and data driven analysis to gain a better understanding at this crucial developmental stage.

Axial view of co-registered multimodal MR data across age. Left to right: T1W, PD, T2W, FA, and MD. Top to bottom: Scans at approximately 2 weeks, 1 year, and 2 years.

Publications:

• N. Sadeghi, M. Prastawa, J.H. Gilmore, W. Lin, G. Gerig. “Spatio-Temporal Analysis of Early Brain Development,” In Proceedings IEEE Asilomar Conference on Signals, Systems & Computers, pp. (in print). 2010.
• N. Sadeghi, M. Prastawa, J.H. Gilmore, W. Lin, G. Gerig. “Towards Analysis of Growth Trajectory through Multi-modal Longitudinal MR Imaging,” In SPIE Medical Imaging 2010: Image Processing, Vol. 7623, 76232U, Edited by Benoit M. Dawant and David R. Haynor, pp. (published online). March, 2010. DOI: 10.1117/12.844526

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Research Projects

• Autism Centers of Excellence
• Early brain development in infants at risk for mental illness
• National Center for Biomedical Computing NA-MIC
• Image Analysis of Pathological changes
• Brain Lesion Modeling and Segmentation
• 4D Analysis of White Matter Diffusion
• 4D Modeling of Image Appearance Changes

PIs

• Guido Gerig
• Marcel Prastawa